Reviewed by Dr. Jason Wright, D.O. · September 23, 2026
The science
How it works
Sets the pulse size
CJC-1295 acts like your own GHRH, preparing the pituitary to release more growth hormone.
Triggers the pulse
Ipamorelin acts on the ghrelin receptor, which signals the actual release.
Raises IGF-1
More growth hormone drives more IGF-1 from the liver, which carries most of the effect.
Spares cortisol and prolactin
Ipamorelin is unusually selective, so it avoids the stress-hormone rise of older peptides.
Human data is limited, and the combination is used by clinical convention.
Dosing
Your dosing plan
Dr. Wright sets your exact dose within this range at your visit.
Starting dose
FormSubcutaneous, bedtime
Dose5 units (100 mcg of each)
Schedule5 nights on, 2 off, 4 weeks
Based onClinical convention
Standard dose
FormSubcutaneous, bedtime
Dose10 units (200 mcg of each)
Schedule4 to 8 more weeks
Based onGuided by labs
Cycle
Form—
Dose8 to 12 weeks on
ScheduleThen 4 weeks off
Based onClinical convention
Side effects
Side effects and what to expect
Redness at the injection siteCommon · First few weeks
Rotate sites. Let the vial reach room temperature first.
Flushing or headacheUncommon · First doses
Usually passes within the first week or two.
Swelling, joint aches, or tingling handsUncommon · Any time
Let us know. These usually mean the dose needs to come down.
Rising blood sugarUncommon · Seen on labs
Dr. Wright monitors this and adjusts your dose.
A note from Dr. Wright
When sermorelin alone isn’t moving the needle, this is my next step. One peptide sets up the pulse, the other pulls the trigger. It’s still your own growth hormone, in your own rhythm, and your IGF-1 keeps us honest.
Dr. Jason Wright, D.O. · Board certified, American Board of Cosmetic Surgery
Cost & access
Getting started with CJC-1295 / Ipamorelin
CJC-1295 / Ipamorelin
CJC-1295 2 mg/mL + ipamorelin 2 mg/mL in one 5 mL vial · Labeled in your name
