Reviewed by Dr. Jason Wright, D.O. · September 23, 2026
The science
How it works
Built from a pineal extract
A four–amino acid peptide modeled on epithalamin, an extract of the pineal gland, which regulates melatonin and circadian rhythm.
Activates telomerase
In cell studies it switched telomerase back on, the enzyme that maintains the protective caps at the ends of chromosomes.
Influences gene expression
Laboratory work suggests it binds regions of DNA and changes which genes are read, though this is early research.
Short, concentrated courses
Given in 10 to 20 day courses once or twice a year rather than continuously.
Most evidence comes from Russian laboratory and small clinical studies.
Dosing
Your dosing plan
Dr. Wright sets your exact dose within this range at your visit.
Course
FormSubcutaneous, evening
Dose5 mg (50 units)
ScheduleDaily for 10 to 20 days
Based onRussian clinical use
If directed
FormSubcutaneous, evening
Dose10 mg (100 units)
ScheduleDaily for 10 days
Based onRussian clinical use
Frequency
Form—
DoseOnce or twice a year
ScheduleA 20-day course at 5 mg uses two vials
Based onClinical practice
Side effects
Side effects and what to expect
Redness at the injection siteCommon · During the course
Rotate sites.
DrowsinessUncommon · During the course
Usually mild.
HeadacheUncommon · First doses
Stay hydrated.
Allergic reactionRare · Any time
Stop and contact the practice.
A note from Dr. Wright
Epitalon is the most speculative thing I prescribe, and I treat it that way: short courses once or twice a year, not something you stay on. The telomere research is intriguing and it is still early.
Dr. Jason Wright, D.O. · Board certified, American Board of Cosmetic Surgery
Cost & access
Getting started with Epitalon
Epitalon
50 mg in a 5 mL vial (10 mg/mL) · Labeled in your name
