Reviewed by Dr. Jason Wright, D.O. · September 23, 2026
The science
How it works
Focus (Semax)
Semax is a fragment of ACTH that raises BDNF, a growth factor tied to learning and memory, without acting as a stimulant.
Calm (Selank)
Selank is a synthetic analog of tuftsin that eases anxiety through GABA and serotonin signaling, without sedation.
Balanced together
Selank smooths the slight edge some people feel on Semax, so the goal is clearer thinking without restlessness.
Nasal delivery
Both are absorbed through the nasal lining, the route used in Russian clinical practice for decades.
Each peptide has Russian clinical and animal research behind it. The combination itself has not been studied as a single product.
Dosing
Your dosing plan
Dr. Wright sets your exact dose within this range at your visit.
Standard protocol
FormNasal spray, morning
Dose1 spray in each nostril (500 mcg of each)
ScheduleOnce daily, 5 days on, 2 off
Based onPharmacy labeling, clinical practice
Starting
FormNasal spray
Dose1 spray in one nostril (250 mcg of each)
ScheduleFirst week
Based onClinical practice
Course
Form—
Dose2 to 4 weeks
ScheduleThen 2 to 4 weeks off
Based onClinical practice
Side effects
Side effects and what to expect
Nasal irritation or runny noseCommon · First few days
Alternate nostrils. Let us know if it persists.
Trouble sleepingUncommon · If taken later in the day
Use it in the morning only.
HeadacheUncommon · First week
Stay hydrated.
Mood changesRare · Any time
Let us know promptly.
A note from Dr. Wright
Some patients want the clarity of Semax without its edge, and that is where adding Selank makes sense. One spray gives you both. Short courses, mornings only, and if nothing changes in two weeks, we stop.
Dr. Jason Wright, D.O. · Board certified, American Board of Cosmetic Surgery
Cost & access
Getting started with Semax / Selank
Semax / Selank
15 mL nasal spray (Semax 2.5 mg/mL + Selank 2.5 mg/mL, 250 mcg of each per spray) · Labeled in your name
15 mL nasal spray (Semax 2.5 mg/mL, Selank 2.5 mg/mL)$225
Questions
Common questions
Combo or single spray?
Choose Semax alone for focus, Selank alone for calm, or the combo if you want both. The combo costs less than buying the two separately.
Can I take it with my antidepressant?
Only with Dr. Wright’s review, and not started at the same time as a new medication.
How do I use the spray?
Prime it before the first use, keep your head upright, and spray into the nostril while breathing in gently. Refrigerate after opening and keep it out of light.
Is it approved?
Both are approved in Russia as nasal drops, not by the FDA. Yours is compounded by a licensed 503A pharmacy.
